MicroCosmos Imaging Systems · Cosmo PSA

Particle Size Analyzer for 0.5–2500 µm Measurement in India

Cosmo PSA is a 21 CFR Part 11 compliant particle size and shape analysis system for Indian laboratories — measuring count, size and shape parameters with D values from D1 to D100, intelligent agglomerate separation, and non-editable, human-readable reporting.

21 CFR Part 11 compliant D10, D50, D90 & all D values 0.5–2500 µm range Cosmo-PSA I & Cosmo-PSA II

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Cosmo PSA particle size analyzer microscope with software on monitor

Cosmo PSA I / Cosmo PSA II

0.5–2500 µmParticle size measurement range

D1–D100All D values, including D10, D50, D90

21 CFR Part 11Full compliance with audit trails & e-signatures

4.9/5Rated across 55 reviews

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Cosmo PSA is a particle size analyzer for Indian laboratories that measures 0.5–2500 µm particles, reports D1–D100 values, and supports 21 CFR Part 11 compliant workflows. It helps pharma, R&D, and QC teams generate repeatable particle size and shape data with audit-ready reporting.

Cosmo PSA quick specifications
Measurement range	0.5 µm – 2500 µm
Particle size distribution	D10, D50, D90 and all D values from D1 to D100
Shape parameters	Sphericity, elongation, circularity, roundness, aspect ratio, solidity, convexity
Regulatory compliance	21 CFR Part 11 — electronic records, e-signatures, audit trails
Models available	Cosmo-PSA I (manual/standard) & Cosmo-PSA II (with individual API/placebo particle identification)
Camera	Cosmo-Captor, made in Germany — 5 MP USB 2.0 standard; 10 MP / 12 MP USB 3.0 options
Compatible microscopes	Any make/model (manual); Zeiss, Nikon, Leica, Olympus and others (motorized)
Typical applications	API particle sizing, placebo & injectables, 96-well plates, yeast cells, crystallinity, R&D/QC

Every Particle Matters

Particle size analyzers and motorized stage microscopes, 21 CFR Part 11 compliant

Cosmo PSA is MicroCosmos' particle size analysis platform for API, placebo, injectables, 96-well plates, yeast cells, crystallinity and other pharmaceutical and industrial applications. It combines precision microscopy with automated image analysis software to deliver accurate, repeatable particle size and shape data.

The system captures count, size parameters and shape parameters, classifies particles by method and size, and calculates particle size distribution as per D values — D10, D50, D90 and all D values ranging from D1 to D100.

Every report is generated as a non-editable, human-readable template, and the full system — including qualification documentation (IQ, OQ and PQ) — is built for 21 CFR Part 11 compliance from the ground up.

Cosmo PSA particle size analysis overview visuals

Why laboratories choose Cosmo PSA

Cosmo PSA combines microscopy-based particle size and shape analysis with D-value reporting from D1 to D100, intelligent agglomerate separation, and non-editable reporting for regulated workflows.

★★★★★ 4.9/5 rating based on 55 reviews

Technical review

Mangesh Ulhare

Technical Head, MicroCosmos Imaging Systems Pvt Ltd

This page has been technically reviewed for product accuracy, particle size analysis workflow relevance, and compliance-related feature descriptions for laboratory buyers in India.

Advanced particle size analysis

What Cosmo PSA measures, at a glance

0.5 µm to 2500 µm

Full particle size measurement range covered by the platform.

D10, D50, D90, all D values

Particle size distribution reported across the complete D-value spectrum.

Advanced agglomerate identification

Distinguishes genuine particles from clustered agglomerates.

Auto calibration & verification

Built-in routines keep measurement accuracy on track between runs.

21 CFR Part 11 compliant

Designed to meet FDA electronic records and signatures requirements.

Non-editable report templates

Human-readable, locked reports suitable for regulated submissions.

Advanced particle shape & morphology

When particle size alone isn’t enough

Cosmo PSA goes beyond size, measuring key shape descriptors for a fuller characterization of every particle.

Sphericity

Elongation

Circularity

Roundness

Length Width Area Perimeter Equivalent Diameter Max Feret Diameter Aspect Ratio Solidity Convexity

Example single-particle measurement output — Particle ID 5

Length414.05 µm

Width252.14 µm

Area22394.81 µm²

Perimeter1567.88 µm

Equivalent Diameter168.86 µm

Max Feret Diameter465.51 µm

Aspect Ratio1.00

Circularity0.11

Solidity0.56

Convexity0.70

Sphericity0.11

Elongation1.64

Cosmo PSA

Every measured parameter, backed by a 21 CFR Part 11 compliant, audit-ready report.

ModelsCosmo-PSA I · Cosmo-PSA II

Size range0.5 – 2500 µm

D valuesD1 to D100

Compliance21 CFR Part 11

Call +91 94 04 888 222 Chat on WhatsApp

21 CFR Part 11 compliant

Electronic records, signatures and full audit trails

Electronic records

Secure, structured digital records for every analysis run.

Electronic signatures

Signed approvals built into the workflow.

Secure data storage

Protected storage for raw data, images and reports.

Audit trails

Complete, tamper-evident audit trail of every action.

Auto backup & restore

Automated backup routines protect against data loss.

Digital data access 24×7

Round-the-clock access to records for authorized users.

User authentication

Role-based login controls access to the system.

Login controls

Access restricted by authenticated user roles.

Versioning

Full version history retained for every record.

Data security

Protected against unauthorized access or tampering.

Cosmo-Captor

Camera and system calibration

Cosmo-Captor — camera, made in Germany

Resolution — 5 MP, USB 2.0, 1/2.5" CMOS
Pixel size — 2.2 × 2.2 micron
Software — image grabbing and annotation module as per 21 CFR Part 11
Other camera options — 10 MP USB 3.0; 12 MP USB 3.0

System calibration and validation

Calibration of the system with NPL traceability
Standard particle slide for result validation

Motorized particle size analysis system

For standard glass slide (25 × 75 mm) analysis

Complete sample scanning with 21 CFR Part 11 compliance, qualification documentation, D values, intelligent agglomerate separation, and digital archiving of the test slide at higher magnification. Can be adapted to selected microscope models — Zeiss, Nikon, Leica, Olympus and others.

Motorized Cosmo PSA microscope with software on monitor

Motorized system overview

Complete sample scanning
21 CFR Part 11 compliance
Qualification documentation — IQ, OQ and PQ
D values (D10, D50, D90) and intelligent agglomerate separation
Digitally archived test slide at higher magnification

Microscope with motorized XY stage and joystick for standard glass slide analysis

Standard glass slide (25 × 75 mm)

Microscope with motorized XY scanning stage; motorized focusing (Z)
Joystick for XYZ navigation
Stage control, image acquisition and analysis software complying with 21 CFR Part 11
Software modules — Cosmo-PSA I and II

Models

Cosmo-PSA I and Cosmo-PSA II

Both models share the same acquisition, measurement and reporting engine — choose the configuration that fits your lab's workflow.

Particle Size Analyzer

Cosmo-PSA I

Acquisition and batch run
Measurements — count, size parameters, shape parameters
Method setting and size classification
Particle size distribution as per D values — D10, D50, D90 and all D values from D1 to D100
Non-editable, human-readable report generation
21 CFR Part 11 compliance

Particle Size Analyzer

Cosmo-PSA II

Only on PSA II
Identifies and measures APIs and placebo particles individually within a mixed formulation
Acquisition and batch run
Measurements — count, size parameters, shape parameters
Method setting and size classification
Particle size distribution as per D values — D10, D50, D90 and all D values from D1 to D100
Non-editable, human-readable report generation
21 CFR Part 11 compliance

Applications

Where labs put Cosmo PSA to work

Api

API particle sizing

Particle size and shape analysis for active pharmaceutical ingredients.

Placebo & injectables

Size and shape characterization for placebo formulations and injectables.

96-well plate analysis

Automated particle counting and sizing within 96-well plate formats.

Yeast cells

Size, count and morphology analysis for yeast cell samples.

Crystallinity

Shape and size characterization to support crystallinity studies.

General R&D & QC

Repeatable particle size analysis for research and quality control labs.

Frequently asked questions

Common questions about Cosmo PSA

What is Cosmo PSA used for?

Cosmo PSA is used for particle size and shape analysis in pharma, research, and quality control laboratories. It measures particle count, size parameters, shape parameters, and D-value distribution for a wide range of sample types.

What particle size range does Cosmo PSA measure?

Cosmo PSA measures particles from 0.5 µm to 2500 µm. The system reports D-values across the full range from D1 to D100.

Does Cosmo PSA report D10, D50, and D90?

Yes. Cosmo PSA reports D10, D50, D90, and all D-values from D1 to D100.

Is Cosmo PSA 21 CFR Part 11 compliant?

Yes. Cosmo PSA is designed for 21 CFR Part 11 compliant workflows with audit-ready reporting, electronic records, and controlled reporting processes.

What is the difference between Cosmo-PSA I and Cosmo-PSA II?

Both models support acquisition, measurement, D-value reporting, and compliant reporting workflows. Cosmo-PSA II additionally identifies and measures API and placebo particles individually within mixed formulations.

Does Cosmo PSA measure particle shape as well as size?

Yes. Cosmo PSA measures particle morphology in addition to size, including circularity, elongation, sphericity, aspect ratio, and related shape descriptors.

Can Cosmo PSA work with an existing microscope?

The manual PSA can be attached to any make or model of microscope, while the motorized version can be adapted to selected microscope models including Zeiss, Nikon, Leica, and Olympus.

Which labs is Cosmo PSA suitable for?

Cosmo PSA is suitable for pharmaceutical, industrial, research, and quality control laboratories that need repeatable particle characterization and documentation-ready reporting.

Every Particle Matters

Accurate D values, intelligent agglomerate separation, and audit-ready reporting — built into every Cosmo PSA system.

Tell us your sample type and regulatory requirements — our team will recommend Cosmo-PSA I or II and arrange a demo.

Call +91 94 04 888 222 Chat on WhatsApp Download Brochure (PDF)

Office402, Brand Square, Kunjir Chowk, Pimple Saudagar, Pune – 411027

Phone+91 94 04 888 222

Emailmangesh@microcosmos.in

ManufacturerMicroCosmos Imaging Systems Pvt Ltd

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