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Nikon SMZ25 / SMZ18 Research Stereomicroscope | 25:1 Zoom Stereo Microscope India | MicroCosmos
Nikon Research Stereomicroscope · MicroCosmos

Nikon SMZ25 / SMZ18 Research Stereomicroscope

From whole organism to single cell — in one zoom sweep.

A breakthrough stereo microscope platform for molecular, cell, developmental and systems biology — engineered with Nikon's Perfect Zoom System for a large zoom ratio, unmatched resolution, and exceptional fluorescence transmission.

Up to 25:1 Zoom Ratio SHR Plan Apo Apochromatic Optics Auto Link Zoom (ALZ) Fly-Eye Epi-Fluorescence
Nikon SMZ25 / SMZ18 research stereomicroscope, full body studio shot

What is the Nikon SMZ25 / SMZ18?

The SMZ25 and SMZ18 are research-grade stereomicroscopes built around Nikon's Perfect Zoom System — the SMZ25 with a motorized 25:1 zoom ratio (0.63–15.75X), the SMZ18 with a manual 18:1 zoom ratio (0.75–13.5X). Both share SHR Plan Apo apochromatic objectives delivering up to 1100 LP/mm resolution, a fly-eye lens epi-fluorescence attachment for uniform low-magnification brightness, and Nikon's oblique coherent contrast (OCC) illumination. The SMZ25 additionally offers Auto Link Zoom for seamless field-of-view matching across objectives and a remote controller with LCD status display. Together they're built for imaging that spans whole organisms down to single-cell detail, with full Digital Sight camera and NIS-Elements software support.

Key Features

Breakthrough Zoom Range & Resolution

Traditional boundaries between molecular biology, cell biology, neurobiology, embryology and systems biology are disappearing — researchers need imaging systems that span scales from single cells to whole organisms. The SMZ25 / SMZ18 was engineered to answer that need.

SHR Plan Apo series objective lenses delivering great zoom range and high resolution on the SMZ25/SMZ18

Large Zoom Range Enables High-Resolution Macro-to-Micro Imaging

Nikon's Perfect Zoom System makes it possible, for the first time, to achieve a zoom ratio of 25:1 (zoom range 0.63X–15.75X) on the SMZ25. Even at 1X, the SMZ25 captures an entire 35mm dish while simultaneously resolving microscopic detail — the SMZ18 delivers the same optical philosophy across an 18:1 range (0.75X–13.5X).

Perfect Zoom System25:1 / 18:1 Ratio

Uncompromised Resolution With True-to-Life Colour

The SHR Plan Apo series of objectives offers a high resolution of 1100 LP/mm (observed value, using SHR Plan Apo 2X at maximum zoom), delivering brilliant images with true-to-life colours. Side-by-side resolution charts show markedly sharper detail and lower colour aberration than a conventional stereo microscope of comparable class.

SHR Plan Apo Optics1100 LP/mm Resolution
Auto Link Zoom (ALZ) on the SMZ25 supporting seamless viewing at different magnification scales

Auto Link Zoom (ALZ) Supports Seamless Viewing at Different Scales

ALZ automatically adjusts the zoom factor to maintain the same field of view when switching objective lenses on the SMZ25. This enables seamless switching between whole-organism imaging at low magnification and detailed imaging at high magnification, without manually recomposing the frame.

Auto Link ZoomSMZ25 Only
SMZ25/SMZ18 zoom body showing significant improvements in optical performance

Zoom Body With Significant Improvements in Optical Performance

A newly developed short-wavelength, high-transmission lens improves signal and reduces noise in fluorescent images. Combined with an innovative epi-fluorescence attachment, the SMZ25 / SMZ18 detects emission signal better than conventional fluorescent stereo microscopes — all housed in a compact, ergonomic zoom body.

High-Transmission OpticsCompact Zoom Body
Key Features

Fluorescence-Ready Illumination

The SMZ25 / SMZ18 series is the first stereo microscope in the world to use a fly-eye lens on an epi-fluorescence attachment — engineered for uniform brightness and a drastically improved signal-to-noise ratio.

Enhanced Brightness at Low Magnification

A built-in fly-eye lens on the epi-fluorescence attachment ensures bright, uniform illumination even at low magnifications, delivering uncompromised uniformity across a large field of view — unlike conventional attachments, which suffer poor illumination coverage at the edges.

Improved S/N Ratio, Crystal-Clear Fluorescence

Nikon's newly developed optical system offers a drastic improvement in signal-to-noise ratio even at high magnifications, making it possible to capture low fluorescence signals and light-sensitive events such as live cell division.

4 Filter Cubes, Fly-Eye Built-In

Epi-fluorescence attachments mount up to 4 filter cubes with a built-in fly-eye lens — available as the motorized P2-EFLM2 (SMZ25) or manual P2-EFLI2 attachment.

Multichannel Imaging

Capture multiple fluorescent channels alongside brightfield or OCC imaging with NIS-Elements, then overlap them into a single multicolour composite for whole-embryo or whole-organism analysis.

Illumination

Easy-to-Use OCC Illumination

The LED DIA Base with a built-in OCC illuminator generates minimal heat, consumes very little power, and is long-lived — enhancing contrast on colourless, transparent, or uneven-surfaced specimens such as embryos.

Oblique Illumination

Slide-Lever Controlled OCC

  • Lights samples diagonally rather than straight from below
  • Reveals contrast in colourless, transparent structures — no staining needed
  • Slide lever with printed scale to save & reproduce a chosen illumination level
  • OCC plate insertable from front or rear for different shadow directions

What Is OCC Illumination?

OCC stands for oblique coherent contrast — a form of oblique lighting developed by Nikon. Compared to conventional diascopic illumination that lights samples directly from below, OCC applies coherent light diagonally, giving contrast to colourless and transparent sample structures without staining.

The OCC illuminator is controlled using a slide lever; scales on the lever let users save and reproduce a desired illumination level. An OCC plate can be inserted from the front or rear of the illumination unit, so images with different shadow direction can be observed.

Oblique Coherent ContrastLow-Heat LED DIA Base
Ergonomics

User-Friendly Remote Controller

Designed for full one-handed control of zoom and focus, for either right- or left-handed use.

SMZ25 remote controller with LCD monitor showing zoom factor, objective lens, filter cube and LED DIA brightness at a glance

Zoom & Focus Control at a Glance

The SMZ25's remote controller provides easy access to zoom and focus, with an LCD monitor and adjustable backlight that displays the zoom factor, objective lens, filter cube, and LED DIA brightness — so users can keep their eyes on the specimen while adjusting settings.

On-axis imaging: with the P2-RNI2 Intelligent Nosepiece, simply slide the objective lens to switch between stereo position (stereoscopic view) and mono position (on-axis view) for digital capture.

Ambidextrous ControllerLCD Status Display
Digital Imaging

Wide Range of Digital Imaging Capabilities

Pair the SMZ25 / SMZ18 with the Digital Sight camera series and NIS-Elements to capture Z drive position, zoom factor, objective lens, filter cube and LED DIA brightness alongside every image.

NIS-Elements Imaging Software

Nikon's flagship, cross-platform imaging software works across both light microscope and stereo microscope systems, enabling a wide range of advanced digital imaging workflows on the SMZ25 and SMZ18.

Multichannel (Multicolour)

Capture multiple fluorescent channels in conjunction with other imaging methods such as OCC or brightfield, then overlap individual colour images into a single composite.

Time-Lapse Imaging

Set up time-lapse experiments easily with NIS-Elements — ideal for capturing dynamic biological events such as neuron firing or embryonic development over time.

Extended Depth of Focus (EDF)

Capture multiple high-resolution images at different focal depths and combine them into a single extended depth-of-focus or quasi-3D composite image.

Versatile Optics

Compatible With Multiple Observation Methods

Using the appropriate stands and attachments, the SMZ25 / SMZ18 supports five distinct observation techniques for broader research versatility.

Brightfield Observation

High-quality, uniformly illuminated images across the SHR Plan Apo zoom range — the standard observation method available on every configuration.

Epi-Fluorescence Observation

The P2-EFLM2 (motorized, SMZ25) or P2-EFLI2 (manual) epi-fluorescence attachment mounts up to 4 filter cubes with a built-in fly-eye lens for bright, uniform fluorescence even at low magnification.

Dark Field Observation

The P-DF LED Dark Field Unit uses oblique illumination to reveal light scattered by unstained, transparent specimens against a dark background.

Simple Polarizing Observation

The P2-POL Simple Polarizing Attachment enables birefringence studies, useful for crystal, mineral, and certain biological specimen analysis.

Oblique Lighting (OCC)

Nikon's oblique coherent contrast illumination gives contrast to colourless, transparent structures such as embryos, without staining — controllable via a calibrated slide lever.

Technical Data

Full Specifications

Complete technical specifications for the Nikon SMZ25 (motorized) and SMZ18 (manual) research stereomicroscopes, as published in the official Nikon SMZ25/18 brochure.

Zooming Body
Optical systemParallel-optics type (zooming type), apochromatic optical system — Perfect Zoom System
ZoomSMZ25Motorized  ·  SMZ18Manual
Zoom ratioSMZ2525:1  ·  SMZ1818:1
Zoom rangeSMZ250.63–15.75X  ·  SMZ180.75–13.5X
Aperture diaphragmZooming body built-in
Objectives — SHR Plan Apo Series (NA, Working Distance)
P2-SHR Plan Apo 2XSMZ25NA 0.312, WD 20mm (correction ring for water, 0–3mm depth)  ·  SMZ18NA 0.3, WD 20mm (correction ring for water, 0–3mm depth)
P2-SHR Plan Apo 1.6XSMZ25NA 0.25, WD 30mm  ·  SMZ18NA 0.24, WD 30mm
P2-SHR Plan Apo 1XSMZ25NA 0.156, WD 60mm  ·  SMZ18NA 0.15, WD 60mm
P2-SHR Plan Apo 0.5XSMZ25NA 0.078, WD 71mm  ·  SMZ18NA 0.075, WD 71mm
Optics, Tubes & Focusing
Total magnification (10X eyepieces)SMZ253.15–315X (depending on objective)  ·  SMZ183.75–270X (depending on objective)
Eyepieces (F.O.V., mm)C-W 10XB (22) · C-W 15X (16) · C-W 20X (12.5) · C-W 30X (7)
Tubes (eyepiece/port) P2-TERG 100 Trinocular Tilting Tube (100/0 : 0/100)
P2-TERG 50 Trinocular Tilting Tube (100/0 : 50/50) — inclination 0–30°
P2-TL100 Trinocular Tube L (100/0 : 0/100) — inclination 10°
Focusing unit (stroke from parfocal point)P2-MFU Motorized Focus Unit (up 96mm / down 4mm)  ·  P2-FU Focus Unit (up 97mm / down 5mm)
Focus mount adapter / nosepiece P2-FM Focus Mount Adapter · P2-RNI2 Intelligent Nosepiece (2 objectives)
SMZ18 only P2-FMDN Focus Mount (for P-PS32, P-DSL32, P-DFS32 stands)
Bases, Stages & Illumination
Bases / stands P2-PB Plain Base · P2-DBL LED Diascopic Illumination Base (OCC illuminator built-in) · P2-DBF Fiber Diascopic Illumination Base
SMZ18 only P-PS32 Plain Stand · P-DSL32 Diascopic Illumination Stand · P-DFS32 Fiber Diascopic Illumination Stand
StagesP-SXY64 Stage · C-SSL Dia-Sliding Stage · C-TRS Tilting Stage
Epi-fluorescence attachments4 filter cubes mountable, fly-eye lens built-in — P2-EFLM2 Motorized Epi Fluorescence Attachment (SMZ25) · P2-EFLI2 Epi Fluorescence Attachment
Episcopic illuminatorsP2-FIRL LED Ring Illumination Unit; with fiber light source — P2-CI Coaxial Epi Illuminator · P2-FIR Ring Fiber Illumination Unit · C-FDF Flexible Double Arm Fiber Illumination Unit
Episcopic light sourceC-FLED2 LED Light Source for fiber illuminator
Observation methodsBrightfield, Epi Fluorescence, Simple Polarizing (with P2-POL attachment), Dark Field (with P-DF LED Dark Field Unit), Oblique Lighting
Weight (approx.) SMZ2532 kg — Motorized Epi Fluorescence configuration with Trinocular Tilting Tube, Motorized Focus Unit, Intelligent Nosepiece, LED DIA base and 1X/0.5X objectives
SMZ1830 kg — Epi Fluorescence configuration with Trinocular Tilting Tube, Focus Unit, Intelligent Nosepiece, LED DIA base and 1X/0.5X objectives
Power consumption (approx.) SMZ2530 W — Motorized Epi Fluorescence configuration with Trinocular Tilting Tube, Motorized Focus Unit, Intelligent Nosepiece and LED DIA base
SMZ1810 W — Epi Fluorescence configuration with Trinocular Tilting Tube, Focus Unit, Intelligent Nosepiece and LED DIA base

P-PS32, P-DSL32, P-DFS32 stands and the P2-FMDN Focus Mount are compatible with SMZ18 only. Specifications subject to change without notice.

Why MicroCosmos Recommends It

SMZ25 / SMZ18 at a Glance

A quick recap of what sets the Nikon SMZ25 / SMZ18 apart as a research stereomicroscope for developmental biology, neurobiology, and whole-organism-to-single-cell imaging.

Industry-Leading Zoom Range

25:1 (SMZ25) or 18:1 (SMZ18) zoom ratio via the Perfect Zoom System — from a full 35mm dish to microscopic detail without changing objectives.

Research-Grade Resolution

SHR Plan Apo apochromatic objectives resolve up to 1100 LP/mm with true-to-life colour and minimal aberration across the full zoom range.

World-First Fluorescence Uniformity

The first stereo microscope to use a fly-eye lens on its epi-fluorescence attachment, for bright, even illumination even at low magnification.

Seamless Scale Switching

Auto Link Zoom (SMZ25) keeps the field of view consistent when moving between objectives, ideal for whole-organism-to-cell workflows.

Five Observation Methods

Brightfield, epi-fluorescence, dark field, simple polarizing and OCC oblique lighting — all on one modular zoom platform.

Full Digital Workflow

Digital Sight cameras and NIS-Elements enable multichannel fluorescence, time-lapse, and extended depth-of-focus imaging out of the box.

FAQ

Frequently Asked Questions

Common questions about the Nikon SMZ25 / SMZ18 research stereomicroscope, answered directly.

What is the Nikon SMZ25 / SMZ18 stereomicroscope?

The SMZ25 and SMZ18 are research-grade stereomicroscopes from Nikon built around the Perfect Zoom System. The SMZ25 offers a motorized 25:1 zoom ratio and the SMZ18 a manual 18:1 zoom ratio, both paired with SHR Plan Apo objectives for high resolution imaging that spans whole organisms down to single-cell detail.

What is Nikon's Perfect Zoom System?

Perfect Zoom System is a breakthrough optical design that dynamically changes the distance between the two optical axes as the zoom factor changes. This maximises light entry at every magnification, delivering a large zoom range, high resolution in both eye paths, and minimal aberration across the entire zoom range in a compact, ergonomic zoom body.

What is Auto Link Zoom (ALZ) on the SMZ25?

Auto Link Zoom automatically adjusts the zoom factor to maintain the same field of view when switching between objective lenses. This enables seamless transitions between low-magnification whole-organism imaging and high-magnification detailed imaging without manually recomposing the field of view.

What observation methods does the SMZ25 / SMZ18 support?

With the appropriate attachments, the SMZ25 / SMZ18 supports brightfield, epi-fluorescence, simple polarizing (with the P2-POL attachment), dark field (with the P-DF LED Dark Field Unit), and oblique lighting via Nikon's OCC illumination.

What is OCC illumination?

OCC stands for oblique coherent contrast, a form of oblique lighting developed by Nikon. Unlike conventional diascopic illumination that lights samples directly from below, OCC applies coherent light diagonally, giving contrast to colourless and transparent sample structures such as embryos.

What resolution do the SHR Plan Apo objectives deliver?

The SHR Plan Apo series objectives deliver a high resolution of 1100 LP/mm as an observed value, using the SHR Plan Apo 2X objective at maximum zoom, producing brilliant images with true-to-life colour and minimal chromatic aberration.

Can a camera or software be used with the SMZ25 / SMZ18?

Yes. The SMZ25 and SMZ18 work with Nikon's Digital Sight camera series and NIS-Elements imaging software to capture zoom factor, objective lens, filter cube and LED DIA brightness information alongside images, and support multichannel fluorescence, time-lapse, and extended depth of focus (EDF) imaging.

What is the difference between the SMZ25 and SMZ18?

The SMZ25 has a motorized zoom body with a 25:1 zoom ratio (0.63-15.75X), a remote controller with LCD status display, and supports Auto Link Zoom. The SMZ18 has a manual zoom body with an 18:1 zoom ratio (0.75-13.5X). Both share the same Perfect Zoom System optical design and SHR Plan Apo objective line.

Bring the SMZ25 / SMZ18 Into Your Lab

MicroCosmos is your authorized source for the Nikon SMZ25 / SMZ18 research stereomicroscope. Talk to our team for pricing, a live demo, or help configuring the right stand, illumination, and objectives for your workflow.

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